DNA repair detailed explanations
What you'll learn
Introduction
Base excision repair
Nucleotide repair
Mismatch repair
Double standard repair
Applications
Conclusion
Dna ligation sticky ends
Bluntends
restricted endonuclease part1
restricted endonuclease part2
Requirements
Any Life student can learn
Description
IntroductionBase excision repairNucleotide repairMismatch repairDouble standard repairApplicationsDNA ligation sticky endsBlunt endsrestricted endonuclease part1restricted endonuclease part2DNA repair definitionDNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.Who discovered DNA repairTomas Lindahl, Paul Modrich and Aziz Sancar are awarded the Nobel Prize in Chemistry 2015 for having mapped and explained how the cell repairs its DNA and safeguards the genetic information.Damaged to DNA caused by replication errors or mutations may have serious consequences.The cell possesses an inbuilt system to repair the damaged DNA .This may be achieved by 4 distinct mechanisms.1.Base excision repair2.nucleotide excision repair3.Mismatch repair4.Double strand break repair.Base Excision Repair is a repair mechanism that corrects damaged DNA by identifying damaged bases and replacing damaged bases with the correct nucleotide.The correct nucleotide can be identified by referencing the complementary strand in the DNA pair based on the Watson-Crick DNA base pairing.DNA bases are constantly subjected to damages like deamination or alkylation. The damaged base is often called the "A basic Site" or "AP site".Damaged bases are first identified by DNA glycosylases. DNA glycosylases are enzymes that are capable of detecting initial lesions of DNA.you can find more details in presentation slides.
Overview
Section 1: Introduction
Lecture 1 Introduction
Lecture 2 Base excision repair
Lecture 3 Nucleotide Repair
Lecture 4 Mismatch Repair
Lecture 5 Double standard break repair
Lecture 6 Applications
Lecture 7 Conclusion
Lecture 8 DNA Ligation sticky ends
Lecture 9 Bluntends
Lecture 10 Restricted Endonuclease part1
Lecture 11 Restricted Endonuclease part2
for all life students
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