It is an idea of authors to write comparative study books to understand the advanced technologies in a comparative way. The objective of writing this book is to understand the programming concepts and uses of C and Python programming language in an easier way. This book consists comparative ten chapters. In chapter one describe general introduction about language such as what is language?, history of language , features of language in simple words. In the chapter number 2,3,4,5 & 6 describes purpose and uses of tokens, operators, control structures, function in programming languages with example. In next chapters describes arrays, strings, structure, pointers and file handling concepts. At the end of the book reference books are mentioned.