Dendrimer-Based Drug Delivery Systems: From Theory to Practice By Binghe Wang(eds.)
2012 | 533 Pages | ISBN: 0470460059 | PDF | 8 MB
The opportunities and challenges of using dendrimers to improve drug deliveryAmong pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have noted that the volume of a dendrimer increases when it has a positive charge. If this property can be applied effectively, dendrimers have enormous potential in drug delivery systems, directly supplying medication to targeted human organs. With contributions from an international team of pioneers and experts in dendrimer research, this book provides a comprehensive overview of the latest research efforts in designing and optimizing dendrimer-based drug delivery systems. The book analyzes key issues, demonstrating the critical connections that link fundamental concepts, design, synthesis, analytical methodology, and biological assessment to the practical use of dendrimers in drug delivery applications. Topics covered include: Dendrimer historySynthesisPhysicochemical propertiesPrinciples of drug deliveryApplications in diverse biomedical fieldsDendrimer-Based Drug Delivery Systems reflects the authors' thorough review and analysis of the current literature as well as their own firsthand experience in the lab. Readers will not only discover the current state of the science, but also gain valuable insights into fruitful directions for future research. References at the end of each chapter serve as a gateway to the growing body of literature in the field, enabling readers to explore each individual topic in greater depth. Pharmaceutical and biomedical researchers will find this book a unique and essential guide to the opportunities, issues, and challenges involved in fully exploiting the potential of dendrimers to improve drug delivery.Content: Chapter 1 Dendrimer Chemistry: Supramolecular Perspectives and Applications (pages 1-54): Charles N. Moorefield, Sujith Perera and George R. NewkomeChapter 2 Physicochemical Properties of Dendrimers and Dendrimer Complexes (pages 55-92): Toyoko ImaeChapter 3 The Use of Dendrimers to Optimize the Physicochemical and Therapeutic Properties of Drugs (pages 93-137): Nicole Stieger, Wilna Liebenberg, Marique E. Aucamp and Melgardt M. De VilliersChapter 4 Biological Properties of Phosphorus Dendrimers (pages 139-155): Anne?Marie Caminade and Jean?Pierre MajoralChapter 5 Dendrimer?Based Prodrugs: Synthesis and Biological Evaluation (pages 157-206): Mohammad Najlah, Zhengyuan Zhou and Antony D'EmanueleChapter 6 Improving the Biocompatibility of Dendrimers in Drug Delivery (pages 207-237): Yiwen Li, Libo Zhao and Yiyun ChengChapter 7 Degradable Dendrimers for Drug Delivery (pages 239-305): Marc Gingras and Myriam RoyChapter 8 Design of Stimuli?Responsive Dendrimers for Biomedical Purposes (pages 307-327): Chie KojimaChapter 9 Dendrimer?Based Gene Delivery Systems: Administration Routes and In Vivo Evaluation (pages 329-354): M. J Santander?Ortega, I. F. Uchegbu and A. G. SchatzleinChapter 10 Triazine Dendrimers for DNA and siRNA Delivery: Progress, Challenges, and Opportunities (pages 355-406): Meredith A. Mintzer, Olivia M. Merkel, Thomas Kissel and Eric E. SimanekChapter 11 Dendrimer?Coated Carbohydrate Residues as Drug Delivery Trojan Horses in Glycoscience (pages 407-438): Yoann M. Chabre and Rene RoyChapter 12 Nuclear Magnetic Resonance Techniques in the Analysis of Pamam Dendrimer?Based Drug Delivery Systems (pages 439-461): Xueyan Feng, Kun Yang, Jingjing Hu, Tongwen Xu and Yiyun ChengChapter 13 Dendrimer?Based Medical Nanodevices for Magnetic Resonance Imaging Applications (pages 463-478): Hongdong Cai, Mingwu Shen and Xiangyang ShiChapter 14 Dendrimer?Related Nanoparticle System for Computed Tomography Imaging (pages 479-500): Chen Peng and Xiangyang Shi