Enzyme Catalysis in Organic Synthesis: A Comprehensive Handbook, Second Edition By
2002 | 1593 Pages | ISBN: 3527299491 | PDF | 47 MB
Organic synthesis with enzymes - the only way This comprehensive set gives reliable answers to all questions on enzyme catalysis - from searching for suitable catalytic systems via choosing the optimal reaction conditions to implementing modern synthesis strategies. The long-awaited new edition has been greatly expanded to include new topics and to reflect the latest research, yet retains the clear and practice-oriented presentation found in the first edition. More than a mere data collection, the three volumes provide synthetic chemists with easy access to all the first-hand information necessary for successfully using enzymes: - the latest synthesis methods - example applications arranged according to reaction type - a table of all the important, commercially available enzymes - comprehensive registers for targeted searching according to enzyme, compound, or reaction - current references to the literature In short, an indispensable reference that should be on the shelf of every modern synthesis laboratory. Content: Chapter 1 Introduction (pages 1-39): Maria?Regina KulaChapter 2 Production and Isolation of Enzymes (pages 41-66): Yoshihiko HiroseChapter 3 Rational Design of Functional Proteins (pages 67-93): Tadayuki Imanaka and Haruyuki AtomiChapter 4 Enzyme Engineering by Directed Evolution (pages 95-138): Oliver May, Christopher A. Voigt and Frances H. ArnoldChapter 5 Enzyme Bioinformatics (pages 139-162): Kay HofmannChapter 6 Immobilization of Enzymes (pages 163-184): James Lalonde and Alexey MargolinChapter 7 Reaction Engineering for Enzyme?Catalyzed Biotransformations (pages 185-257): Manfred Biselli, Udo Kragl and Christian WandreyChapter 8 Enzymic Conversions in Organic and Other Low?Water Media (pages 259-285): Peter HallingChapter 9 Enzymatic Kinetic Resolution (pages 287-312): Jonathan M. J. Williams, Rebecca J. Parker and Claudia NeriChapter 10 Enzymes from Extreme Thermophilic and Hyperthermophilic Archaea and Bacteria (pages 313-334): Costanzo Bertoldo and Garabed AntranikianChapter 11 Hydrolysis and Formation of Carboxylid Acid Esters (pages 335-578): Hans Joachim Gais and Fritz TheilChapter 11 Hydrolysis of Epoxides (pages 579-608): Kurt Faber and Romano V. A. OrruChapter 11 Hydrolysis and Formation of Glycosidic Bonds (pages 609-653): Chi?Huey WongChapter 11 Natural Polysaccharide?Degrading Enzymes (pages 653-685): Constanzo Bertoldo and Garabed AntranikianChapter 11 Addition of Water to C=C Bonds (pages 686-697): Marcel WubboltsChapter 12 Hydrolysis of Nitriles (pages 699-715): Birgit SchulzeChapter 12 Formation and Hydrolysis of Amides (pages 716-740): Birgit Schulze and Erik De VroomChapter 12 Hydrolysis of N?Acylamino Acids (pages 741-761): Andreas S. BommariusChapter 12 Hydrolysis and Formation of Hydantoins (pages 761-799): Markus Pietzsch and Christoph SyldatkChapter 12 Hydrolysis and Formation of Peptides (pages 800-865): Hans?Dieter JakubkeChapter 12 Addition of Amines to C = C Bonds (pages 866-872): Marcel WubboltsChapter 12 Transaminations (pages 873-893): J. David Rozzell and Andreas S. BommariusChapter 13 Formation and Cleavage of P?O Bonds (pages 895-929): George M. WhitesidesChapter 14 Formation of C?C Bonds: Sections 14.1 ? 14.6 (pages 931-974): Chi?Huey WongChapter 14 Formation of C?C Bonds: Enzymatic Synthesis of Cyanohydrins (pages 974-989): Martin H. Fechter and Herfried GrienglChapter 15 Reduction of Ketones (pages 991-1033): Kaoru Nakamura and Tomoko MatsudaChapter 15 Reduction of Various Functionalities (pages 1033-1047): Kaoru Nakamura and Tomoko MatsudoChapter 15 Reduction of C=N bonds (pages 1047-1063): Andreas S. BommariusChapter 16 Oxygenation of C?H and C?C Bonds (pages 1065-1108): Sabine Flitsch, Gideon Grogan and D. AshcroftChapter 16 Oxidation of Alcohols (pages 1108-1170): Andreas Schmid, Frank Hollmann and Bruno BuhlerChapter 16 Oxidation of Phenols (pages 1170-1194): Andreas Schmid, Frank Hollmann and Bruno BuhlerChapter 16 Oxidation of Aldehydes (pages 1194-1202): Andreas Schmid, Frank Hollmann and Bruno BuhlerChapter 16 Baeyer?Villiger Oxidations (pages 1202-1245): Sabine Flitsch and Gideon GroganChapter 16 Oxidation of Acids (pages 1245-1250): Andreas Schmid, Frank Hollmann and Bruno BuhlerChapter 16 Oxidation of C?N Bonds (pages 1250-1261): Andreas Schmid, Frank Hollmann and Bruno BuhlerChapter 16 Oxidation at Sulfur (pages 1262-1266): Karl?Heinz van PeeChapter 16 Halogenation (pages 1267-1280): Karl?Heinz van PeeChapter 17 Isomerazation (pages 1281-1332): Nobuyoshi Esaki, T. Kurihara and K. SodaChapter 18 Introduction and Removal of Protecting Groups (pages 1333-1417): Dieter Kadereit, Reinhard Reents, Duraiswamy A. Jeyaraj and Herbert WaldmannChapter 19 Replacing Chemical Steps by Biotransformations: Industrial Application and Processes Using Biocatalysis (pages 1419-1459): Andreas LieseChapter 20 Tabular Survey of Commercially Available Enzymes (pages 1461-1518): Peter Rasor