Inflammation and Allergy Drug Design By
2011 | 326 Pages | ISBN: 1444330144 | PDF | 10 MB
Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit.Inflammation and Allergy Drug Design explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators. This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduatestudents and clinicians with a basic understanding of allergic diseases in the respiratory tract.Content: Chapter 1 Novel Anti?Inflammatory Drugs Based on Targeting Lung Dendritic Cells and Airway Epithelial Cells (pages 1-14): Bart N. Lambrecht, Maud Plantinga, Monique Willart and Hamida HammadChapter 2 Role of Th2 Cells in the Allergic Diathesis (pages 15-25): Marsha Wills?karpChapter 3 Importance of Th17? and Th1?Associated Responses for the Development of Asthma (pages 27-38): Tomohiro Yoshimoto, Hiroko Tsutsui and Kenji NakanishiChapter 4 Regulatory T Cells (pages 39-57): Chris Corrigan and Kimuli RyannaChapter 5 A Role for Natural Killer T?Cell Subsets in the Pathogenesis of Various Allergic Disorders (pages 59-66): Hiroshi Watarai, Michishige Harada, Mayumi Tamari and Masaru TaniguchiChapter 6 Regulatory Roles of B Cells in Allergy and Inflammation (pages 67-77): Kiyoshi Takatsu, Masashi Ikutani and Yoshinori NagaiChapter 7 Mast Cells (pages 79-105): Mindy Tsai and Stephen J. GalliChapter 8 Eosinophils (pages 107-121): Nancy A. Lee, Mark V. Dahl, Elizabeth A. Jacobsen and Sergei I. OchkurChapter 9 Basophils in Inflammation and Allergy Drug Design (pages 123-137): Donald MacGlashanChapter 10 Epithelial Cells (pages 139-148): Tillie?Louise Hackett, Stephanie Warner, Dorota Stefanowicz and Darryl KnightChapter 11 Fibroblasts (pages 149-162): Alastair G. Stewart, Lilian Soon and Michael SchuligaChapter 12 Airway Smooth Muscle Cells (pages 163-171): Andrew J. Halayko and Pawan SharmaChapter 13 Interleukin 4, Interleukin 13, and Interleukin 9 (pages 173-185): Kenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi and Shoichi SuzukiChapter 14 Interleukin 3, Interleukin 5, and Granulocyte-Macrophage Colony?Stimulating Factor (pages 187-196): Alba Llop?Guevara, Josip Marcinko, Ramzi Fattouh and Manel JordanaChapter 15 Interleukin 15, Interleukin 17, and Interleukin 25 (pages 197-204): Hiroshi Nakajima and Itsuo IwamotoChapter 16 Thymic Stromal Lymphopoietin (pages 205-214): Kazuhiko Arima and Yong?Jun LiuChapter 17 Interleukin 10 (pages 215-224): Whitney W. Stevens, Larry Borish and John W. SteinkeChapter 18 Tumor Necrosis Factor Alpha (pages 225-235): Christopher Brightling, Latifa Chachi, Dhan Desai and Yassine AmraniChapter 19 Profibrotic and Angiogenic Factors in Asthma (pages 237-252): Neville Berkman and Francesca Levi?SchafferChapter 20 Chemokines (pages 253-261): Luis M. Teran and Juan R. VelazquezChapter 21 Epithelial Growth Factors (pages 263-270): Yasuhiro Gon and Shu HashimotoChapter 22 Prostanoids (pages 271-283): Sarah A. Maher, Deborah L. Clarke and Maria G. BelvisiChapter 23 Leukotrienes (pages 285-295): Katsuhide Okunishi and Marc Peters?GoldenChapter 24 Proteases in Allergy (pages 297-305): Keisuke Oboki and Hirohisa SaitoChapter 25 Toll?Like Receptors (pages 307-316): Jessica L. Allen, Aurelien Trompette and Christopher L. Karp