Management of Chemical and Biological Samples for Screening Applications By
2012 | 420 Pages | ISBN: 352732822X | PDF | 5 MB
Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of this emerging discipline, from compound acquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of expertise gathered by several large pharmaceutical companies to current and future challenges in high-throughput screening. With its treatment of libraries of small molecules as well as biobanks containing biomolecules, microorganisms and tissue samples, this reference is universally applicable for any molecular scientist involved in a large screening program.Content: Chapter 1 Introduction to Sample Management (pages 1-7): William P. Janzen and Andy ZaayengaChapter 2 Generating a High?Quality Compound Collection (pages 9-21): Philip B. Cox and Anil VasudevanChapter 3 Assessing Compound Quality (pages 23-44): Ioana Popa?Burke, Stephen Besley and Zoe BlaxillChapter 4 Delivering and Maintaining Quality within Compound Management (pages 45-58): Isabel CharlesChapter 5 Obtaining and Maintaining High?Quality Tissue Samples: Scientific and Technical Considerations to Promote Evidence?Based Biobanking Practice (EBBP) (pages 59-81): Lisa B. MirandaChapter 6 Thinking Lean in Compound Management Laboratories (pages 83-105): Michael AllenChapter 7 Application of Supply Management Principles in Sample Management (pages 107-120): Paul A. GosnellChapter 8 Solid Sample Weighing and Distribution (pages 121-142): Michael Gray and Snehal BhattChapter 9 Managing a Global Biological Resource of Cells and Cellular Derivatives (pages 143-164): Frank P. Simione and Raymond H. CypessChapter 10 Development of Automation in Sample Management (pages 165-197): Gregory J. WendelChapter 11 Applications of Acoustic Technology (pages 199-219): Eric Tang, Colin Bath and Sue Holland?CrimminChapter 12 Enhancing Biorepository Sample Integrity with Automated Storage and Retrieval (pages 221-242): Johann van NiekerkChapter 13 Information Technology Systems for Sample Management (pages 243-263): Brian BrooksChapter 14 Key Features of a Compound Management System (pages 265-273): Clive BattleChapter 15 What Does an HTS File of the Future Look Like? (pages 275-304): Francois BertelliChapter 16 New Enabling Technology (pages 305-350): Neil Hardy, Ji Yi Khoo, Shoufeng Yang, Holger Eickhoff, Joe Olechno and Richard EllsonChapter 17 The Impact of Future Technologies within Biobanking (pages 351-366): Manuel M. Morente, Laura Cereceda and Maria J. ArtigaChapter 18 Outsourcing Sample Management (pages 367-379): Sylviane Boucharens and Amelia Wall WarnerChapter 19 Sample Management Yesterday and Tomorrow (pages 381-391): Dr. Terry Wood and Dr. Mark Wigglesworth