New York, 1921: acclaimed photographer Alfred Stieglitz celebrates the success of his latest exhibition-the centerpiece, a series of nude portraits of his soon-to-be wife, the young Georgia O'Keeffe. The exhibit acts as a turning point for the painter poised to make her entrance into the art scene. There she meets Rebecca Salsbury, the fiancé of Stieglitz's protégé, Paul Strand, marking the start of a bond between the couples that will last more than a decade and reverberate throughout their lives. In the years that followed, O'Keeffe and Stieglitz become the preeminent couple in American modern art, spurring on each other's creativity. Observing their relationship leads Salsbury to encourage new artistic possibilities for Strand and to rethink her own potential as an artist.