English | 2022 | ISBN: 1119691699 | 512 pages | True PDF EPUB | 27.1 MB
Fundamentals of DRUG DEVELOPMENT Enables readers to understand the process of pharmaceutical research, its regulatory basis, and how it fits into the global healthcare environment
This book discusses how to conduct pharmaceutical research and the context for how the industry fits into global healthcare. Holistically, the well-qualified author helps readers and students of drug development appreciate the time and expense of the process. Specifically, the work identifies the emerging trends shaping the future of drug development, along with important related topics like generic drugs, data sharing, and collaboration.

Glen McNamara, "Dirty Work: When Police Are Protecting Drug Dealers and Paedophiles, Someone Has to Act. A True Story"
English | 2011 | ISBN: 1741108519 | 201 pages | AZW3 / EPUB / MOBI | 5 MB
This true story of police corruption and undercover assignments will have you reeling. "All crime revolves around the financial powerhouse that is the drug trade. And drugs and paedophilia go together like a hand in a glove." This is Inner Sydney in the heat of the 1980s and the cash and drugs are flowing freely.

Bircher A Cutaneous Drug Hypersensitivity 2022 | 11.7 MB
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New applications of nmr in drug discovery and development By
2013 | 584 Pages | ISBN: 1849734445 | PDF | 17 MB
Content: Introduction; Part I. Small Molecules, Proteins, Cellular Systems: New Applications of High; Resolution NMR in Drug Discovery and Development; Solid-state NMR in Drug Discovery and Development; Part II. The Whole Organism in Vivo: Increased Sensitivity Using Cryogenic; Radiofrequency Coils: Application to In Vivo Phenotyping of Mice; Recent Developments of Contrast Agents, CEST and Low Fields; Pharmacological fMRI in Drug Discovery and Development; Part III. Translational drug discovery: From Biological Models to the Clinics; Translational Magnetic Resonance Imaging and Spectroscopy: Opportunities and Challenges

Drug Design Strategies Computational Techniques and Applications By D Livingstone; Andrew M Davis
2012 | 516 Pages | ISBN: 1849731675 | PDF | 136 MB
This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems biology. The aim of the book is to show how various facets of the drug discovery process can be addressed in a quantitative fashion (ie: numerical analysis to enable robust predictions to be made). Each chapter includes a brief review of the topic showing the historical development of quantitative approaches, a survey/summary of the current state-of-the-art, a selection of well chosen examples with some worked through and an appreciation of what problems remain to be overcome as well as an indication of how the field may develop. After an overview of quantitative approaches to drug design the book describes the development of concepts of "drug-like properties", of quantitative structure-activity relationships and molecular modelling, and in particular, structure-based design approaches to guide lead optimisation. How to manage and describe chemical structures, underpins all quantitative approaches to drug design and these are described in the following chapters. The next chapter covers the value of a quantitative approach, and also the challenge which is to describe the confidence in any prediction, and methods to assess predictive model quality. The later chapters describe the application of quantitative approaches to describing and optimising potency, selectivity, drug metabolism and pharmacokinetic properties and toxicology, and the design of chemical libraries to feed the screening approaches to lead generation that underpin modern drug discovery. Finally the book describes the impact of bioinformatics, current status of predicting ligand affinity direct from the protein structure, and the application of quantitative approaches to predicting environmental risk. The book provides a summary of the current state-of-the-art in quantitative approaches to drug design, and future opportunities, but it also provides inspiration to drug design practitioners to apply careful design, to make best use of the quantitative methods that are available, while continuing to improve them. Drug discovery still relies heavily on random screening and empirical screening cascades to identify leads and drugs and the process has many failures to deliver only a small handful of drugs. With the rapidly escalating costs of drug discovery and development together with spiralling delivery, quantitative approaches hold the promise of shifting the balance of success, to enable drug discovery to maintain its economic viability.

Anti-Inflammatory Drug Discovery By Jeremy I Levin; Stefan Laufer
2012 | 528 Pages | ISBN: 1849734135 | PDF | 65 MB
Content: Section 1. Arachidonic acid cascade -- section 2. Kinases -- section 3. GPCRs -- section 4. Sphingolipids -- section 5. Steroid hormone receptors

New Delivery Systems for Controlled Drug Release from Naturally Occurring Materials By Nicholas Parris, LinShu Liu, Cunxian Song, and V. Prasad Shastri (Eds.)
2008 | 315 Pages | ISBN: 084127424X | PDF | 36 MB
Content: Efficacy assessment of hyaluronan vehicles for sustained release of pDNA / Weiliam Chen ... [et al.] -- A new soy-based hydrogel: development, viscoelasic properties and application for controlled drug release / Zengshe Liu and Sevin Z. Erhan -- Application of lipases to develop novel acyltransferase substrates / Thomas McKeon ... [et al.] -- Controlled release of indomethacin from spran-dried chitosan microspheres containing microemulsion / Jun Bae Lee ... [et al.] -- Synbiotic matrices derived from plant oligosaccharides and polysaccharides / Arland T. Hotchkiss ... [et al.] -- Significant role of naturally occurring materials in drug delivery technology for tissue regeneration therapy / Yasuhiko Tabata -- PH and temperature sensitive block copolymer hydrogels based on poly(ethylene glycol) and sulfamethazine / Doo Sung Lee, Woo Sun Shim, and Dai Phu Huynh -- Engineering of solid lipid nanoparticles / Jie Huang Peng ... [et al.] -- Antibody modified collagen matrix for site-specific gene delivery / Xu Jin ... [et al.] -- A review: controlled release systems for agricultural and food applications / LinShu Liu, Marshall F. Fishman, and Kevin B. Hicks -- State of the art mass spectrometric and chromatographic techniques for residue analysis / Katerina Mastovska.

English | 2023 | ISBN: 1719646406 | 1504 pages | True EPUB | 4.59 MB
Davis's Drug Guide for Nurses®, Eighteenth Edition delivers everything you need to administer medications safely across the lifespan—643 well-organized monographs encompassing hundreds of generic drugs and thousands of trade names.

Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation By Bente Steffansen M.Sc.(Pharm), Ph.D. (auth.), Yuichi Sugiyama, Bente Steffansen (eds.)
2013 | 317 Pages | ISBN: 0120323079 | PDF | 6 MB
Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters' impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

English | 2021 | ISBN: 1975183371 | 1824 pages | True EPUB | 8.14 MB
THE #1 Drug Guide for nurses & other clinicians