Free Download Natural Product Based Drug Discovery Against Human Parasites: Opportunities and Challenges
English | 2023 | ISBN: 9811996040 | 1034 Pages | PDF EPUB (True) | 52 MB
This book comprehensively reviews current and novel treatment strategies against human parasites, including protozoans and helminths, using natural products. The initial chapters summarize the conventional treatment strategies and natural-product based therapeutics against these parasites. It discusses biochemical tools and techniques for the discovery of natural product based drugs against human parasites. The book also covers the ingenious and innovative mechanisms to achieve drug resistance by the protozoan parasites and strategies to overcome the resistance. It entails mechanistic insight into the modulation of host immune responses to delay or inhibit parasite clearance and explores host-pathogen interactions that mediate immunity against subsequent parasite challenge. In turn, the volume helps in understanding the immunobiology of the parasites and tools to identify candidate vaccine antigens and novel delivery systems against the protozoan parasites. Lastly, it explores the role of advanced methods, including nanotechnology, marine bioprospecting, and microorganisms-derived biochemicals against the protozoan parasites.

Free Download Claudine Hellmuth, "Collage Discovery Workshop: Make Your Own Collage Creations Using Vintage Photos, Found Objects and Ephemera"
English | 2003 | pages: 131 | ISBN: 1581803435 | PDF | 60,9 mb
Unlock the Artist Within

Free Download Penny Van Oosterzee, "A New Human: the Startling Discovery and Strange Story of the ''Hobbits'' of Flores, Indonesia"
English | 2016 | pages: 288 | ISBN: 1598744143, 1138403571 | EPUB | 8,4 mb
In the most revolutionary archaeological find of the new century, an international team of archaeologists led by Mike Morwood discovered a new, diminutive species of human on the remote Indonesian island of Flores. Nicknamed the "Hobbit," this was no creation of Tolkien's fantasy. The three foot tall skeleton with a brain the size of a chimpanzee's was a tool-using, fire-making, cooperatively hunting person who inhabited Flores alongside modern humans as recently as 13,000 years ago. This book is Morwood's description of this monumental discovery and the intense study that has been undertaken to validate his view of its relationship to our species. He chronicles the bitter debates over Homo Floresiensis, the objections (some spiteful) of colleagues, the theft and damage of some of the specimens, and the endless battle against government and academic bureaucracies that hindered his research. This updated paperback edition contains an epilogue that reports on the most recent debates, findings, and analyses of this amazing discovery.

Free Download The Journey Of Self Discovery 2024
Published 12/2023
MP4 | Video: h264, 1920x1080 | Audio: AAC, 44.1 KHz
Language: English | Size: 894.54 MB | Duration: 0h 52m
Discover more about how you can improve your quality of living by discovering how to build self belief, and self esteem.

Free Download High Performance Computing for Drug Discovery and Biomedicine
English | 2023 | ISBN: 1071634488 | 783 Pages | PDF EPUB (True) | 55 MB
This volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The first section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. The second section delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step and readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls.

Free Download Drug Repurposing and Computational Drug Discovery: Strategies and Advances
English | 2024 | ISBN: 1774912775 | 294 Pages | PDF (True) | 14 MB
Drug repurposing is defined as identifying new pharmacological indications from old, existing, failed, investigational, already marketed, or FDA-approved drugs and prodrugs, and applying these new uses in the treatment of diseases other than the drug's original intended therapeutic use. The application of computational techniques in discovery research not only helps in the development of drugs from leads or existing drug molecules but can also be useful for the repurposing of existing drug candidates.

Free Download Drug Discovery and Design Using Natural Products
English | 2023 | ISBN: 3031352041 | 553 Pages | PDF EPUB (True) | 49 MB
Historically, natural products have great relevance for the development of new drugs. Natural molecules, in addition to directly providing new compounds with different therapeutic functions have provided scaffolds and a great diversity of structures that serve as inspiration for the design and discovery of new drugs. The great structural complexity and the significant number of natural compounds that can be obtained and their advantages also present some historical problems that need to be overcome. Issues such as difficulty in isolation, difficulty in synthesizing compounds found in nature in the laboratory, screening to evaluate the biological properties of these compounds, and structural optimization to enhance the pharmacological properties of biomolecules; are some of the main difficulties encountered in research with natural products and in the design/discovery of new medicines. Therefore, this book addresses the great scientific advances that provide practical solutions to using natural products to develop new drugs. We address topics related to the genesis of research projects that use natural products to design new drugs. We address the discovery of new species, initial processes for identification and extraction of compounds, isolation and identification of these structures, techniques, and advances in vitro and in vivo methods that support the discovery of new natural drugs, synthesis of new compounds from natural molecules, in silico optimization processes of potentially promising compounds.

Free Download Computational Drug Discovery and Design (2nd Edition)
English | 2023 | ISBN: 1071634402 | 656 Pages | PDF EPUB (True) | 56 MB
This second edition provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput virtual screening, lead discovery and optimization, conformational sampling, prediction of pharmacokinetic properties using computer-based methodologies. Chapters also focus on the application of the latest artificial intelligence technologies for computer aided drug discovery. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.

Mysterious Glowing Mammals An Unexpected Discovery Sparks a Scientific Investigation by Maria Parrott-Ryan PDF | 5.56 MB
N/A | 60 Pages

Title: Mysterious Glowing Mammals
Author: Maria Parrott-Ryan
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The Worlds I See Curiosity, Exploration, and Discovery at the Dawn of AI by Fei-Fei Li M4B | 663.96 MB
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